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Article

Rac1 protects epithelial cells against anoikis.

The Journal of biological chemistry - 27 Jul 2001

Coniglio S J, Jou T S, Symons M

Abstract excerpt

Rho family members play a critical role in malignant transformation. Anchorage-independent growth and the ability to avoid apoptosis caused by loss of anchorage (anoikis) are important features of transformed cells. Here we show that constitutive activation of Rac1 inhibits anoikis in Madin-Darby canine kidney (MDCK) epithelial cells. Constitutively active Rac1-V12 decreases DNA fragmentation and caspase activity...

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Source

Identifiers

PMID: 11369774
DOI: 10.1074/jbc.M102299200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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