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Article

Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells.

FEBS letters - 8 May 2002

Jeong Hye-Gwang, Cho Hyun-Ju, Chang In-Youb, Yoon Sang-Pil, Jeon Young-Jin, Chung Myung-Hee, You Ho Jin

Abstract excerpt

In this study, the role of V12-Rac1 in the cisplatin-induced apoptosis was investigated. Cisplatin-induced apoptosis is associated with cytochrome c release, which can be inhibited by V12-Rac1 expression. The analysis of mitogen-activated protein kinase activity indicated that V12-Rac1 expression led to a decrease in p38 activity after exposure to cisplatin but not c-jun N-terminal kinase and extracellular...

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Source

Identifiers

PMID: 11997032
DOI: 10.1016/s0014-5793(02)02674-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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