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Article

Ras mutation promotes p53 activation and apoptosis of skin keratinocytes.

Carcinogenesis - 1 Aug 2006

Zhao Yunfeng, Chaiswing Luksana, Bakthavatchalu Vasudevan, Oberley Terry D, St Clair Daret K

Abstract excerpt

Previous studies in our laboratory demonstrated that 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) treatment induced apoptosis and mitochondrial translocation of the tumor suppressor p53 in a mouse skin carcinogenesis model, suggesting that oncogenic versus cell death signaling involve a common mediator. Mutational activation of oncogenic Ras is an early event and has been...

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Identifiers

PMID: 16613839
DOI: 10.1093/carcin/bgl037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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