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Article

Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells.

Molecular and cellular biology - 1 Aug 2003

Zhang Baolin, Zhang Yaqin, Shacter Emily

Abstract excerpt

The Rac members of the Rho family GTPases control signaling pathways that regulate diverse cellular activities, including cytoskeletal organization, gene transcription, and cell transformation. Rac is implicated in apoptosis, but little is known about the mechanism by which it responds to apoptotic stimuli. Here we demonstrate that endogenous Rac GTPases are caspase 3 substrates that are cleaved in human lymphoma...

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Identifiers

PMID: 12897143
DOI: 10.1128/MCB.23.16.5716-5725.2003
PMCID: PMC166330

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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