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Article

Prima-1 induces apoptosis in bladder cancer cell lines by activating p53.

Clinics (Sao Paulo, Brazil) - 1 Jan 2013

Piantino Camila B, Reis Sabrina T, Viana Nayara I, Silva Iran A, Morais Denis R, Antunes Alberto A, Dip Nelson, Srougi Miguel, Leite Katia R

Abstract excerpt

OBJECTIVES: Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer...

Topics

Apoptosis Regulatory Proteins
Carcinoma
Cell Line, Tumor
Gene Expression
Genes, p53
Humans
Mutation
Neoplasm Proteins
Real-Time Polymerase Chain Reaction
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Urinary Bladder Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 23644847
DOI: 10.6061/clinics/2013(03)oa03
PMCID: PMC3611750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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