Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase.

Oncogene - 31 Jul 1997

Lorès P, Morin L, Luna R, Gacon G

Abstract excerpt

Rac proteins constitute a subgroup of the Rho family of small GTPases and include Rac1, which is expressed ubiquitously, and Rac2, a highly homologous protein only expressed in myelo-monocytic and lymphoid cell lineages. In fibroblasts, Rac1 plays a crucial role in control of actin cytoskeleton organisation, cell growth and Ras-induced transformation. In phagocytes, Rac1 and Rac2 regulate a specific enzymatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Flow Cytometry
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Mutation

Share to Recombinant Proteins

Source

Identifiers

PMID: 9247314
DOI: 10.1038/sj.onc.1201378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase.PMID 9247314Read ↗

Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency.Semantic proximity Read ↗

Rac2 Hyperactivity Drives Neutrophil Degranulation, Myeloperoxidase Deficiency, and LymphopeniaSemantic proximity Read ↗

Rac GTPases in human diseases.Semantic proximity Read ↗

Rac GTPases in Human DiseasesSemantic proximity Read ↗

Combined Immunodeficiency Caused by a Novel De Novo Gain-of-Function RAC2 MutationSemantic proximity Read ↗

Combined Immunodeficiency Caused by a Novel De Novo Gain-of-Function RAC2 Mutation.Semantic proximity Read ↗

Rac2, a Hematopoiesis-Specific Rho GTPase, Specifically Regulates Mast Cell Protease Gene Expression in Bone Marrow-Derived Mast CellsSemantic proximity Read ↗

Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcomaSemantic proximity Read ↗

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.Semantic proximity Read ↗

Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus.Semantic proximity Read ↗

Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.Semantic proximity Read ↗

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.