Article
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.
Oncogene - 27 Sept 2001
Mullan P B, Quinn J E, Gilmore P M, McWilliams S, Andrews H, Gervin C, McCabe N, McKenna S, White P, Song Y H, Maheswaran S, Liu E, Haber D A, Johnston P G, Harkin D P
Abstract excerpt
BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian cancer. Induction of BRCA1 in the presence of Taxol and Vincristine resulted in a dramatic increase...
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