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Article

BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.

The Journal of biological chemistry - 8 Mar 2002

Fan Wenhong, Jin Shunqian, Tong Tong, Zhao Hongcheng, Fan Feiyue, Antinore Michael J, Rajasekaran Baskaran, Wu Min, Zhan Qimin

Abstract excerpt

BRCA1, a breast and ovarian cancer susceptibility gene, has been implicated in gene regulation. Previous studies demonstrate that BRCA1 induces GADD45, a p53-regulated and stress-inducible gene that plays an important role in cellular response to DNA damage. However, the mechanism(s) by which BRCA1 regulates GADD45 remains unclear. In this report, we have shown that BRCA1 activation of the GADD45 promoter is...

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Source

Identifiers

PMID: 11777930
DOI: 10.1074/jbc.M110225200

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.PMID 11777930Read ↗

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