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Article

BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.

The Journal of biological chemistry - 8 Mar 2002

Fan Wenhong, Jin Shunqian, Tong Tong, Zhao Hongcheng, Fan Feiyue, Antinore Michael J, Rajasekaran Baskaran, Wu Min, Zhan Qimin

Abstract excerpt

BRCA1, a breast and ovarian cancer susceptibility gene, has been implicated in gene regulation. Previous studies demonstrate that BRCA1 induces GADD45, a p53-regulated and stress-inducible gene that plays an important role in cellular response to DNA damage. However, the mechanism(s) by which BRC...

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Source

Identifiers

PMID: 11777930
DOI: 10.1074/jbc.M110225200

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11777930-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.PMID 11777930Read ↗

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the <i>GADD45</i> Promoter in the Absence of Direct DNA BindingSemantic proximity Read ↗

Analysis of GADD45A sequence variations in French Canadian families with high risk of breast cancer.Semantic proximity Read ↗

Comprehensive search for X-ray-responsive elements and binding factors in the regulatory region of the GADD45a gene.Semantic proximity Read ↗

Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations.Semantic proximity Read ↗

The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis.Semantic proximity Read ↗

Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway.Semantic proximity Read ↗

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma.Semantic proximity Read ↗

A polymorphism but no mutations in the GADD45 gene in breast cancers.Semantic proximity Read ↗

The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.Semantic proximity Read ↗

BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.Semantic proximity Read ↗

GADD45a promoter regulation by a functional genetic variant associated with acute lung injury.Semantic proximity Read ↗

Gadd45a acts as a modifier locus for lymphoblastic lymphoma.Semantic proximity Read ↗

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