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Article

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma.

Breast cancer research and treatment - 1 Sept 2004

Sensi Elisa, Tancredi Mariella, Aretini Paolo, Cipollini Giovanna, Collecchi Paola, Naccarato A Giuseppe, Viacava Paolo, Bevilacqua Generoso, Caligo Maria A

Abstract excerpt

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target...

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Source

Identifiers

PMID: 15377844
DOI: 10.1023/B:BREA.0000041625.60280.4a

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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