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Article

G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells

1 Jul 2002

Abstract excerpt

Microtubule-depolymerizing agents are widely used to synchronize cells, screen for mitotic checkpoint defects, and treat cancer. The present study evaluated the effects of these agents on normal and malignant human breast cell lines. After treatment with 1 microM nocodazole, seven of ten breast cancer lines (type A cells) arrested in mitosis, whereas the other three (type B cells) did not. Similar effects were...

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PMID: 12093892
DOI: 10.1172/jci13275

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