Article
BRCA1-associated growth arrest is RB-dependent.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999
Aprelikova O N, Fang B S, Meissner E G, Cotter S, Campbell M, Kuthiala A, Bessho M, Jensen R A, Liu E T
Abstract excerpt
BRCA1 is a susceptibility gene for breast and ovarian cancer with growth-inhibitory activity for which the mechanism of action remains unclear. When introduced into cells, BRCA1 inhibits growth of some but not all cell lines. In an attempt to uncover the mechanism of growth suppression by BRCA1, we examined a panel of cell lines for their ability to reduce colony outgrowth in response to BRCA1 overexpression. Of...
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