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Article

The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells

1 May 2003

Abstract excerpt

BRCA1 is implicated in cellular responses to DNA damage, thereby substantially contributing to maintenance of the genome integrity. Mutations in the BRCA1 gene occur in breast and ovarian cancer and mutations that disable p53 are frequently found in human cancers, often accompanied by mutations in additional genes, contributing to tumor progression or high-grade malignancy. Therefore, the role of BRCA1 in the...

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PMID: 12684687
DOI: 10.3892/ijo.22.5.1169

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