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Article

Cell-cycle progression and response of germ cell tumors to cisplatin in vitro

1 Aug 2006

Abstract excerpt

Testicular germ cell tumors (GCTs) are highly sensitive to cisplatin-based chemotherapy. It has been suggested that the chemosensitivity of GCTs can be partially attributed to the preference of apoptosis induction over a p21-mediated G1/S phase cell-cycle arrest following induction of p53. Since cell-cycle progression can be manipulated by a growing number of targeted agents, a thorough understanding of the...

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PMID: 16820891
DOI: 10.3892/ijo.29.2.471

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Source receipt: pubmed, retrieved 7 Sept 2026.

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