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Article

BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.

Oncogene - 5 May 2005

Yan Ying, Spieker Rebecca S, Kim Min, Stoeger Scott M, Cowan Kenneth H

Abstract excerpt

Germline mutations in the BRCA1 gene are associated with an increased susceptibility to the development of breast and ovarian cancers. Evidence suggests that BRCA1 protein plays a key role in mediating DNA damage-induced checkpoint responses. Several studies have shown that ectopic expression of...

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Source

Identifiers

PMID: 15735702
DOI: 10.1038/sj.onc.1208492

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15735702-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.PMID 15735702Read ↗

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