Article
The involvement of WT1 in the regulation of GADD45a in response to genotoxic stress.
Mutagenesis - 1 Jul 2013
Johnson Donna, Hastwell Paul W, Walmsley Richard M
Abstract excerpt
Expression of the human GADD45a gene is increased in TK6 cells exposed to mutagens, clastogens and aneugens. It is known to be regulated through both p53-dependent and p53-independent pathways and WT1 has been implicated in both cases. This article reports an investigation into the effect that mutations in the WT1 and p53 response elements of the gene have on GADD45a expression. This was conducted in both p53...
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