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Article

BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer

24 Jun 2011

Abstract excerpt

BRCA1 plays numerous roles in the regulation of genome integrity and chemoresistance. Although BRCA1 interaction with key proteins involved in DNA repair is well known, its role as a coregulator in the transcriptional response to DNA damage remains poorly understood. In this study, we show that BRCA1 plays a central role in the transcriptional response to genotoxic stress in prostate cancer. BRCA1 expression...

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PMID: 21700680
DOI: 10.1158/1541-7786.mcr-11-0155

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