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Article

ARM Domain-dependent Nuclear Import of Adenomatous Polyposis Coli Protein Is Stimulated by the B56α Subunit of Protein Phosphatase 2A

1 Dec 2001

Abstract excerpt

Inactivating mutations in the adenomatous polyposis coli (APC) gene correlate with progression of colon cancer and familial adenomatous polyposis. The APC tumor suppressor contributes to chromosome segregation and turnover of the oncogenic transcriptional activator beta-catenin, and these activities are impaired by truncating cancer mutations. APC was recently identified as a shuttling protein whose subcellular...

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PMID: 11585828
DOI: 10.1074/jbc.m107149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ARM Domain-dependent Nuclear Import of Adenomatous Polyposis Coli Protein Is Stimulated by the B56α Subunit of Protein Phosphatase 2APMID 11585828Read ↗

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Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.Semantic proximity Read ↗

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Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation.Semantic proximity Read ↗

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