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Article

Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation.

Oncogene - 4 Sept 2003

Fagman Henrik, Larsson Fredrik, Arvidsson Yvonne, Meuller Johan, Nordling Margareta, Martinsson Tommy, Helmbrecht Karen, Brabant Georg, Nilsson Mikael

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor is a nucleocytoplasmic protein. The nuclear accumulation of APC was recently found to vary depending on cell density, suggesting that putative APC function(s) in the nucleus is controlled by the establishment of cell contacts. We report here that the density-dependent redistribution of APC between nucleus and cytoplasm prevails in 6/6 thyroid and colorectal...

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Source

Identifiers

PMID: 12955080
DOI: 10.1038/sj.onc.1206731

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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