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Article

The APC tumour suppressor has a nuclear export function.

Nature - 31 Aug 2000

Rosin-Arbesfeld R, Townsley F, Bienz M

Abstract excerpt

The adenomatous polpyposis coli (APC) protein is mutated in most colorectal tumours. Nearly all APC mutations are truncations, and many of these terminate in the mutation cluster region located halfway through the protein. In cancer cells expressing mutant APC, beta-catenin is stabilized and translocates into the nucleus to act as a transcriptional co-activator of T-cell factor. During normal development, APC...

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Identifiers

PMID: 10984057
DOI: 10.1038/35023016

Genes

APC

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