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Article

APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export.

EMBO reports - 1 Dec 2000

Neufeld K L, Zhang F, Cullen B R, White R L

Abstract excerpt

Mutational inactivation of adenomatous polyposis coli (APC) initiates most colon carcinomas. APC functions include targeting cytoplasmic beta-catenin, a Wnt pathway mediator, for proteolysis. Although APC shuttles between cytoplasm and nucleus, the role of nuclear APC protein, particularly with r...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11263497
DOI: 10.1093/embo-reports/kvd117
PMCID: PMC1083789

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11263497-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export.PMID 11263497Read ↗

The APC tumour suppressor has a nuclear export function.Semantic proximity Read ↗

Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation.Semantic proximity Read ↗

ARM Domain-dependent Nuclear Import of Adenomatous Polyposis Coli Protein Is Stimulated by the B56α Subunit of Protein Phosphatase 2ASemantic proximity Read ↗

Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.Semantic proximity Read ↗

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.Semantic proximity Read ↗

Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.Semantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.Semantic proximity Read ↗

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.Semantic proximity Read ↗

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colonSemantic proximity Read ↗

A nuclear function for armadillo/beta-catenin.Semantic proximity Read ↗

Nuclear translocation of beta-catenin in hereditary and carcinogen- induced intestinal adenomasSemantic proximity Read ↗

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