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Article

APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export.

EMBO reports - 1 Dec 2000

Neufeld K L, Zhang F, Cullen B R, White R L

Abstract excerpt

Mutational inactivation of adenomatous polyposis coli (APC) initiates most colon carcinomas. APC functions include targeting cytoplasmic beta-catenin, a Wnt pathway mediator, for proteolysis. Although APC shuttles between cytoplasm and nucleus, the role of nuclear APC protein, particularly with respect to nuclear beta-catenin levels and activity, remains unclear. Here, we demonstrate that APC lacking functional...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11263497
DOI: 10.1093/embo-reports/kvd117
PMCID: PMC1083789

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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