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Article

Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.

The Journal of biological chemistry - 8 Dec 2006

Nadauld Lincoln D, Phelps Reid, Moore Brent C, Eisinger Annie, Sandoval Imelda T, Chidester Stephanie, Peterson Peter W, Manos Elizabeth J, Sklow Bradford, Burt Randall W, Jones David A

Abstract excerpt

Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenesis. The tumor suppressor function of APC is attributed primarily to its ability to regulate the WNT pathway by targeting the destruction of beta-catenin. We report here a novel role for APC...

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Source

Identifiers

PMID: 17028196
DOI: 10.1074/jbc.M602119200

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17028196-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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