Article
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
American journal of human genetics - 1 Dec 2005
Schumacher Johannes, Kaneva Radka, Jamra Rami Abou, Diaz Guillermo Orozco, Ohlraun Stephanie, Milanova Vihra, Lee Young-Ae, Rivas Fabio, Mayoral Fermin, Fuerst Robert, Flaquer Antonia, Windemuth Christine, Gay Eudoxia, Sanz Sebastian, González Maria José, Gil Susana, Cabaleiro Francisco, del Rio Francisco, Perez Fermin, Haro Jesus, Kostov Christian, Chorbov Vesselin, Nikolova-Hill Amelia, Stoyanova Vessela, Onchev George, Kremensky Ivo, Strauch Konstantin, Schulze Thomas G, Nürnberg Peter, Gaebel Wolfgang, Klimke Ansgar, Auburger Georg, Wienker Thomas F, Kalaydjieva Luba, Propping Peter, Cichon Sven, Jablensky Assen, Rietschel Marcella, Nöthen Markus M
Abstract excerpt
We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage...
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