Article
Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.
Translational psychiatry - 24 Feb 2020
Sul Jae Hoon, Service Susan K, Huang Alden Y, Ramensky Vasily, Hwang Sun-Goo, Teshiba Terri M, Park YoungJun, Ori Anil P S, Zhang Zhongyang, Mullins Niamh, Olde Loohuis Loes M, Fears Scott C, Araya Carmen, Araya Xinia, Spesny Mitzi, Bejarano Julio, Ramirez Margarita, Castrillón Gabriel, Gomez-Makhinson Juliana, Lopez Maria C, Montoya Gabriel, Montoya Claudia P, Aldana Ileana, Escobar Javier I, Ospina-Duque Jorge, Kremeyer Barbara, Bedoya Gabriel, Ruiz-Linares Andres, Cantor Rita M, Molina Julio, Coppola Giovanni, Ophoff Roel A, Macaya Gabriel, Lopez-Jaramillo Carlos, Reus Victor, Bearden Carrie E, Sabatti Chiara, Freimer Nelson B
Abstract excerpt
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and...
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