Article
Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2001
Reiner A, Del Mar N, Meade C A, Yang H, Dragatsis I, Zeitlin S, Goldowitz D
Abstract excerpt
To determine whether neurons lacking huntingtin can participate in development and survive in postnatal brain, we used two approaches in an effort to create mice consisting of wild-type cells and cells without huntingtin. In one approach, chimeras were created by aggregating the 4-8 cell embryos from matings of Hdh (+/-) mice with wild-type 4-8 cell embryos. No chimeric offspring that possessed homozygous Hdh...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.