Article
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.
Nature genetics - 1 Dec 1997
White J K, Auerbach W, Duyao M P, Vonsattel J P, Gusella J F, Joyner A L, MacDonald M E
Abstract excerpt
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion that lengthens a glutamine segment in the novel huntingtin protein. To elucidate the molecular basis of HD, we extended the polyglutamine tract of the mouse homologue, Hdh, by targetted...
Topics
- Alleles
- Animals
- Cell Differentiation
- Embryonic and Fetal Development
- Gene Deletion
- Heterozygote
- Homozygote
- Humans
- Huntingtin Protein
- Huntington Disease
- Male
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Mutagenesis, Insertional
- Nerve Tissue Proteins
- Nuclear Proteins
- Phenotype