Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.

doi:10.1016/0092-8674(95)90542-1

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Article

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.

Cell - 2 Jun 1995

Nasir J, Floresco S B, O'Kusky J R, Diewert V M, Richman J M, Zeisler J, Borowski A, Marth J D, Phillips A G, Hayden M R

Abstract excerpt

Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes die before embryonic day 8.5, initiate gastrulation, but do not proceed to the formation of...

Topics

Animals
Base Sequence
Behavior, Animal
Brain
Chimera
Discrimination Learning
Embryo, Mammalian
Female
Genes, Lethal
Heterozygote
Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Huntington Disease

Male

Memory, Short-Term

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Motor Activity

Source

Open in PubMed

Identifiers

PMID: 7774020
DOI: 10.1016/0092-8674(95)90542-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774020-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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