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Article

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.

Cell - 2 Jun 1995

Nasir J, Floresco S B, O'Kusky J R, Diewert V M, Richman J M, Zeisler J, Borowski A, Marth J D, Phillips A G, Hayden M R

Abstract excerpt

Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes die before embryonic day 8.5, initiate gastrulation, but do not proceed to the formation of...

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Identifiers

PMID: 7774020
DOI: 10.1016/0092-8674(95)90542-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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