Article
R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice.
The Journal of comparative neurology - 20 Dec 2007
Reiner Anton, Del Mar Nobel, Deng Yun-Ping, Meade Christopher A, Sun Zhiqiang, Goldowitz Daniel
Abstract excerpt
The R6/2 mouse possesses mutant exon 1 of human Hdh, and R6/2 mice with 150 CAG repeats show neurological abnormalities by 10 weeks and die by 15 weeks. Few brain abnormalities, however, are evident at death, other than widespread ubiquitinated neuronal intranuclear inclusions (NIIs). We constructed R6/2t+/t- <--> wildtype (WT) chimeric mice to prolong survival of R6/2 cells and determine if neuronal death and/or...
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