Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation

1 Oct 2018

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the Huntingtin (HTT) gene. Induced pluripotent stem cell (iPSC) models of HD provide an opportunity to study the mechanisms underlying disease pathology in disease-relevant patient tissues. Murine studies have demonstrated that HTT is intricately involved in corticogenesis. However, the effect of mutant Hungtintin (mtHTT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30355486
DOI: 10.1016/j.celrep.2018.09.076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and MaturationPMID 30355486Read ↗

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read ↗

Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease.Semantic proximity Read ↗

Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions.Semantic proximity Read ↗

Complementary 2D and 3D cultures deriving from a single human cortical differentiation process recapitulate in vitro neurodevelopmental and neurogenerative features of juvenile Huntington’s DiseaseSemantic proximity Read ↗

HUNTINGTON DISEASE ALTERS THE PATTERNING OF NEOCORTICAL AREA IN MICESemantic proximity Read ↗

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neuronsSemantic proximity Read ↗

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read ↗

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.Semantic proximity Read ↗

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington’s Disease and Possible Therapeutic AvenuesSemantic proximity Read ↗

Cellular Models: HD Patient-Derived Pluripotent Stem Cells.Semantic proximity Read ↗

Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids.Semantic proximity Read ↗

iPSC Neurodegenerative Disease Initiative isogenic CAG repeat iPSC line for Huntington’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.