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Early Neurodevelopmental Defects in Huntington’s Disease are Driven by Choroid Plexus Overgrowth and Altered Paracrine Signaling

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD), especially juvenile-onset HD (JOHD), involves early neurodevelopmental pathogenesis alongside the gradual breakdown of the corticostriatal neural axis. To better understand this mechanism, we created fused dorsal–ventral forebrain organoids from induced pluripotent stem cells (iPSCs) from JOHD to mimic early corticostriatal interactions in the disease. We observed char...

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Literature Corpus work
2a86dc06-e2e5-5636-8192-7b03901d1d39
DOI
10.1101/2024.09.23.614496
Open publication

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Early Neurodevelopmental Defects in Huntington’s Disease are Driven by Choroid Plexus Overgrowth and Altered Paracrine SignalingDOI 10.1101/2024.09.23.614496
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