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Article

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.

Nature genetics - 1 Nov 2000

Dragatsis I, Levine M S, Zeitlin S

Abstract excerpt

Inactivation of the mouse homologue of the Huntington disease gene (Hdh) results in early embryonic lethality. To investigate the normal function of Hdh in the adult and to evaluate current models for Huntington disease (HD), we have used the Cre/loxP site-specific recombination strategy to inactivate Hdh expression in the forebrain and testis, resulting in a progressive degenerative neuronal phenotype and...

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Identifiers

PMID: 11062468
DOI: 10.1038/81593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.PMID 11062468Read ↗

Inactivation of the mouse Huntington's disease gene homolog Hdh.Semantic proximity Read ↗

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Hypomorphic mutation of the mouse Huntington’s disease gene orthologueSemantic proximity Read ↗

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Semantic proximity Read ↗

The use of transgenic and knock-in mice to study Huntington's disease.Semantic proximity Read ↗

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