Article
Structure, expression and activation of fish ras genes.
Aquatic toxicology (Amsterdam, Netherlands) - 1 Nov 2001
Rotchell J M, Lee J S, Chipman J K, Ostrander G K
Abstract excerpt
Ras genes encode proteins that play a central role in cell growth signaling cascades. The fish ras genes characterized to date, have a high degree of nucleotide sequence and deduced amino acid similarity with the mammalian ras gene counterparts. A large proportion and wide variety of mammalian tumors possess mutant forms of ras. In such cases, the localization of ras mutations has been restricted to exons I and...
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