Analysis of ras gene mutations in rainbow trout liver tumors initiated by aflatoxin B1.

doi:10.1002/mc.2940040206

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Article

Analysis of ras gene mutations in rainbow trout liver tumors initiated by aflatoxin B1.

Molecular carcinogenesis - 1 Jan 1991

Chang Y J, Mathews C, Mangold K, Marien K, Hendricks J, Bailey G

Abstract excerpt

The suspect human hepatocarcinogen aflatoxin B1 (AFB1) is a well-known potent initiator of hepatic tumors in rainbow trout (Oncorhynchus mykiss). Both hepatocellular carcinomas and mixed hepatocellular/cholangiocellular carcinomas are induced by AFB1 in trout, with the mixed form predominating. We previously isolated two c-ras genes from trout liver cDNA, and in the present study we analyzed DNA from 14...

Topics

Adenoma, Bile Duct
Aflatoxin B1
Aflatoxins
Alleles
Animals
Base Sequence
Cloning, Molecular
Exons
Gene Expression Regulation
Genes, ras
Liver Neoplasms
Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis

Nucleic Acid Hybridization

Oligonucleotide Probes

Plasmids

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1645972
DOI: 10.1002/mc.2940040206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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