Article
A novel population health approach: Using fish retinoblastoma gene profiles as a surrogate for humans.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Mar 2009
Rotchell Jeanette M, du Corbier Frances A, Stentiford Grant D, Lyons Brett P, Liddle Andrew R, Ostrander Gary K
Abstract excerpt
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We have previously shown that two types of fish tumor, eye and liver, also possess mutant Rb genes. Our aim is to determine if the Rb allele status is linked to environmentally-induced cancer and whet...
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