Article
Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
McMahon G, Davis E F, Huber L J, Kim Y, Wogan G N
Abstract excerpt
c-Ki-ras and N-ras oncogenes have been characterized in aflatoxin B1-induced hepatocellular carcinomas. Detection of different protooncogene and oncogene sequences and estimation of their frequency distribution were accomplished by polymerase chain reaction, cloning, and plaque screening methods....
Topics
- Aflatoxin B1
- Aflatoxins
- Amino Acid Sequence
- Animals
- Base Sequence
- Carcinogens
- Codon
- DNA
- DNA, Neoplasm
- Exons
- Genes, ras
- Liver
- Liver Neoplasms, Experimental
- Male
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction