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Article

Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

McMahon G, Davis E F, Huber L J, Kim Y, Wogan G N

Abstract excerpt

c-Ki-ras and N-ras oncogenes have been characterized in aflatoxin B1-induced hepatocellular carcinomas. Detection of different protooncogene and oncogene sequences and estimation of their frequency distribution were accomplished by polymerase chain reaction, cloning, and plaque screening methods. Two c-Ki-ras oncogene sequences were identified in DNA from liver tumors that contained nucleotide changes absent in...

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Identifiers

PMID: 2105496
DOI: 10.1073/pnas.87.3.1104
PMCID: PMC53419

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