Article
Beryllium sensitivity is linked to HLA-DP genotype.
Toxicology - 13 Aug 2001
Wang Z, Farris G M, Newman L S, Shou Y, Maier L A, Smith H N, Marrone B L
Abstract excerpt
Chronic beryllium disease (CBD) appears to arise from a combination of both exposure and genetic risk factors. A distinguishing feature of CBD is beryllium hypersensitivity, which can be measured in vitro by a lymphocyte proliferation test. The objective of this study was to determine whether certain allelic variations of the HLA-DPB1 gene, which had been observed previously in CBD, could be found in a group of...
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