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Article

Definitive hematopoiesis requires the mixed-lineage leukemia gene.

Developmental cell - 1 Mar 2004

Ernst Patricia, Fisher Jill K, Avery William, Wade Stacey, Foy Daniel, Korsmeyer Stanley J

Abstract excerpt

The Mixed-Lineage Leukemia (MLL) gene encodes a Trithorax-related chromatin-modifying protooncogene that positively regulates Hox genes. In addition to their well-characterized roles in axial patterning, Trithorax and Polycomb family proteins perform less-understood functions in vertebrate hematopoiesis. To define the role of MLL in the development of the hematopoietic system, we examined the potential of cells...

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Identifiers

PMID: 15030765
DOI: 10.1016/s1534-5807(04)00061-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Definitive hematopoiesis requires the mixed-lineage leukemia gene.PMID 15030765Read ↗

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Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated TransformationSemantic proximity Read ↗

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