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Article

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

Blood - 12 Feb 2009

Madan Vikas, Madan Babita, Brykczynska Urszula, Zilbermann Frédéric, Hogeveen Kevin, Döhner Konstanze, Döhner Hartmut, Weber Odile, Blum Carmen, Rodewald Hans-Reimer, Sassone-Corsi Paolo, Peters Antoine H F M, Fehling Hans Jörg

Abstract excerpt

The human Mixed-Lineage-Leukemia-5 (MLL5) gene is located in a genomic region frequently deleted in patients with myeloid malignancies and encodes a widely expressed nuclear protein most closely related to MLL1, a Trithorax transcriptional regulator with established involvement in leukemogenesis. Although the physiologic function of MLL5 is completely unknown, domain structure and homology to transcriptional...

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Identifiers

PMID: 18952892
DOI: 10.1182/blood-2008-02-142638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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