Article
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006
Glaser Stefan, Metcalf Donald, Wu Li, Hart Adam H, DiRago Ladina, Mifsud Sandra, D'Amico Angela, Dagger Samantha, Campo Chiara, Chan Angela C, Izon David J, Robb Lorraine
Abstract excerpt
Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression studies have implicated Mixl1 as a regulator of hematopoiesis arising in differentiating embryonic stem cells. To assess the role of Mixl1 in the regulation of adult hematopoiesis, we...
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