Article
Altered Hox expression and segmental identity in Mll-mutant mice.
Nature - 30 Nov 1995
Yu B D, Hess J L, Horning S E, Brown G A, Korsmeyer S J
Abstract excerpt
The mixed-lineage leukaemia gene (MLL/HRX/ALL-1) is disrupted by chromosomal translocation in human acute leukaemias that often display mixed lymphoid-myeloid phenotypes and present in infancy. MLL possesses a highly conserved SET domain also found in Drosophila trithorax (trx) and Polycomb group...
Topics
- Animals
- Cell Line
- Chimera
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Female
- Fetus
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes, Homeobox
- Heterozygote
- Histone-Lysine N-Methyltransferase
- Homozygote
- Humans
- Male
- Mice
- Mutagenesis
- Mutation