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Article

Altered Hox expression and segmental identity in Mll-mutant mice.

Nature - 30 Nov 1995

Yu B D, Hess J L, Horning S E, Brown G A, Korsmeyer S J

Abstract excerpt

The mixed-lineage leukaemia gene (MLL/HRX/ALL-1) is disrupted by chromosomal translocation in human acute leukaemias that often display mixed lymphoid-myeloid phenotypes and present in infancy. MLL possesses a highly conserved SET domain also found in Drosophila trithorax (trx) and Polycomb group (Pc-G) genes, which are known to regulate homeotic genes (HOM-C) in a positive or negative fashion, respectively. Mll...

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Identifiers

PMID: 7477409
DOI: 10.1038/378505a0

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Altered Hox expression and segmental identity in Mll-mutant mice.PMID 7477409Read ↗

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MLL: how complex does it get?Semantic proximity Read ↗

An MLL-dependent network sustains hematopoiesisSemantic proximity Read ↗

Definitive hematopoiesis requires the mixed-lineage leukemia gene.Semantic proximity Read ↗

Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.Semantic proximity Read ↗

Down-regulation of homeobox genes <i>MEIS1</i> and <i>HOXA</i> in <i>MLL</i> -rearranged acute leukemia impairs engraftment and reduces proliferationSemantic proximity Read ↗

New insight into the molecular mechanisms of MLL-associated leukemia.Semantic proximity Read ↗

HOXA9 is required for survival in human MLL-rearranged acute leukemias.Semantic proximity Read ↗

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