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Article

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

Blood - 12 Feb 2009

Heuser Michael, Yap Damian B, Leung Malina, de Algara Teresa Ruiz, Tafech Alaeddin, McKinney Steven, Dixon John, Thresher Rosemary, Colledge Bill, Carlton Mark, Humphries R Keith, Aparicio Samuel A

Abstract excerpt

MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, which frequently is dele...

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Source

Identifiers

PMID: 18854576
DOI: 10.1182/blood-2008-06-162263

Genes

HOXA10
NUP98
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18854576-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.PMID 18854576Read ↗

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