Article
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.
Blood - 12 Feb 2009
Heuser Michael, Yap Damian B, Leung Malina, de Algara Teresa Ruiz, Tafech Alaeddin, McKinney Steven, Dixon John, Thresher Rosemary, Colledge Bill, Carlton Mark, Humphries R Keith, Aparicio Samuel A
Abstract excerpt
MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, which frequently is deleted in myeloid leukemias, suggesting a possible role in hemopoiesis. To address this question, we generated a...
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