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Article

Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos

1 Sept 1997

Abstract excerpt

Translocations involving the mixed lineage leukemia gene (MLL), the human homolog of the Drosophila gene trithorax, are one of the most common genetic alterations in human acute leukemias. Each translocation involving MLL results in loss of one functional copy of MLL and the generation of a chimeric fusion protein with potential dominant negative or neomorphic activity. Mll is a positive regulator of Hox genes,...

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PMID: 9292512
DOI: 10.1182/blood.v90.5.1799

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Defects in Yolk Sac Hematopoiesis in Mll-Null EmbryosPMID 9292512Read ↗

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