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Article

MLL5 (KMT2E): structure, function, and clinical relevance.

Cellular and molecular life sciences : CMLS - 1 Jul 2017

Zhang Xiaoming, Novera Wisna, Zhang Yan, Deng Lih-Wen

Abstract excerpt

The mixed lineage leukemia (MLL) family of genes, also known as the lysine N-methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax group that plays critical roles in the regulation of homeotic gene (HOX) expression and embryonic development. MLL5, assigned as KMT2E on the basis of its SET domain homology, was initially categorized under MLL (KMT2) family together with other...

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Identifiers

PMID: 28188343
DOI: 10.1007/s00018-017-2470-8
PMCID: PMC11107642

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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