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Article

An MLL-dependent network sustains hematopoiesis

21 May 2013

Abstract excerpt

The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although clustered homeobox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains unknown. Here, we identify and characterize part of the Mll-dependent transcriptional network in...

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PMID: 23744037
DOI: 10.1073/pnas.1301278110

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