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Article

Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in <i>Saccharomyces cerevisiae</i>

1 Oct 2001

Abstract excerpt

Sterol levels affect the expression of many genes in yeast and humans. We found that the paralogous transcription factors Upc2p and Ecm22p of yeast were sterol regulatory element (SRE) binding proteins (SREBPs) responsible for regulating transcription of the sterol biosynthetic genes ERG2 and ERG3. We defined a 7-bp SRE common to these and other genes, including many genes involved in sterol biosynthesis. Upc2p...

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Identifiers

PMID: 11533229
DOI: 10.1128/mcb.21.19.6395-6405.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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