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Article

Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

The Journal of biological chemistry - 3 Jun 2016

Burr Risa, Stewart Emerson V, Shao Wei, Zhao Shan, Hannibal-Bach Hans Kristian, Ejsing Christer S, Espenshade Peter J

Abstract excerpt

Eukaryotic lipid synthesis is oxygen-dependent with cholesterol synthesis requiring 11 oxygen molecules and fatty acid desaturation requiring 1 oxygen molecule per double bond. Accordingly, organisms evaluate oxygen availability to control lipid homeostasis. The sterol regulatory element-binding protein (SREBP) transcription factors regulate lipid homeostasis. In mammals, SREBP-2 controls cholesterol...

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Identifiers

PMID: 27053105
DOI: 10.1074/jbc.M116.723650
PMCID: PMC4933267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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