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Article

Transcriptome profiling of Saccharomyces cerevisiae mutants lacking C2H2 zinc finger proteins.

BMC genomics - 1 Jan 2008

Mao Jinghe, Habib Tanwir, Shenwu Ming, Kang Baobin, Allen Wilbur, Robertson LaShonda, Yang Jack Y, Deng Youping

Abstract excerpt

BACKGROUND: The budding yeast Saccharomyces cerevisiae is a eukaryotic organism with extensive genetic redundancy. Large-scale gene deletion analysis has shown that over 80% of the ~6200 predicted genes are nonessential and that the functions of 30% of all ORFs remain unclassified, implying that yeast cells can tolerate deletion of a substantial number of individual genes. For example, a class of zinc finger...

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PMID: 18366603
DOI: 10.1186/1471-2164-9-S1-S14
PMCID: PMC2386056

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