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Nonidentical function of Upc2A binding sites in the Candida glabrata CDR1 promoter

5 Sept 2022

Abstract excerpt

Increased expression of the Candida glabrata CDR1 gene, encoding an ATP-binding cassette membrane transporter, is routinely observed in fluconazole-resistant isolates of this pathogenic yeast. CDR1 transcription has been well-documented to be due to activity of the Zn2Cys6 zinc cluster-containing transcription factor Pdr1. Gain-of-function mutations in the gene encoding this factor are the most commonly observed...

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PMID: 36063046
DOI: 10.1093/genetics/iyac135

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