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Article

Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans.

Molecular microbiology - 1 Aug 2007

Lee Hyeseung, Bien Clara M, Hughes Adam L, Espenshade Peter J, Kwon-Chung Kyung J, Chang Yun C

Abstract excerpt

We investigated the effects of the hypoxia-mimetic CoCl2 in the pathogenic fungus Cryptococcus neoformans and demonstrated that CoCl2 leads to defects in several enzymatic steps in ergosterol biosynthesis. Sterol defects were amplified in cells lacking components of the Sre1p-mediated oxygen-sens...

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Source

Identifiers

PMID: 17645443
DOI: 10.1111/j.1365-2958.2007.05844.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17645443-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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