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Article

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2001

Pouliot J J, Robertson C A, Nash H A

Abstract excerpt

BACKGROUND: The covalent linkage between DNA and the active site tyrosine of topoisomerase I can be stabilized by chemotherapeutic agents, adjacent DNA lesions, or mutational defects in the topoisomerase itself. Following collision with a replication fork, the covalent complex can be converted to a double-strand break. Tdp1, an enzyme that can hydrolyse the bond between topoisomerase I and DNA, is thought to be...

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Source

Identifiers

PMID: 11532027
DOI: 10.1046/j.1365-2443.2001.00452.x

Genes

TDP1
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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