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Article

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death.

The Journal of biological chemistry - 9 May 1997

Megonigal M D, Fertala J, Bjornsti M A

Abstract excerpt

Eukaryotic DNA topoisomerase I catalyzes the relaxation of supercoiled DNA through a concerted mechanism of DNA strand breakage and religation. The cytotoxic activity of camptothecin results from the reversible stabilization of a covalent enzyme-DNA intermediate. Mutations in two conserved region...

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Source

Identifiers

PMID: 9139740
DOI: 10.1074/jbc.272.19.12801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9139740-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death.PMID 9139740Read ↗

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Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I.Semantic proximity Read ↗

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.Semantic proximity Read ↗

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